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Issue 11, 2014
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Nanostructured weathering steel for matrix-free laser desorption ionisation mass spectrometry and imaging of metabolites, drugs and complex glycans

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Abstract

Weathering steel has been employed for the first time to prepare sample plates for matrix-free laser desorption ionisation mass spectrometry (LDI-MS) of small molecules up to a mass range of around 1500 Da. The effective UV absorption, heat conductivity and porosity of the nanostructured inner rust layer formed during passivation determine the excellent performance in LDI-MS for a broad range of different analyte classes. The inexpensive material was evaluated in a series of relevant analytical applications ranging from the matrix-free detection of serum metabolites, lactose quantification, lipid analysis in milk to the glycoprofiling of antibodies and imaging mass spectrometry of brain tissue samples.

Graphical abstract: Nanostructured weathering steel for matrix-free laser desorption ionisation mass spectrometry and imaging of metabolites, drugs and complex glycans

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Publication details

The article was received on 29 Jan 2014, accepted on 11 Mar 2014 and first published on 16 Apr 2014


Article type: Paper
DOI: 10.1039/C4AN00216D
Citation: Analyst, 2014,139, 2873-2883
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    Nanostructured weathering steel for matrix-free laser desorption ionisation mass spectrometry and imaging of metabolites, drugs and complex glycans

    J. Etxebarria, J. Calvo and N. Reichardt, Analyst, 2014, 139, 2873
    DOI: 10.1039/C4AN00216D

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