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Issue 17, 2014
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Synthesis of ZnO nanorods and their application in the construction of a nanostructure-based electrochemical sensor for determination of levodopa in the presence of carbidopa

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Abstract

A novel carbon paste electrode modified with ZnO nanorods and 5-(4′-amino-3′-hydroxy-biphenyl-4-yl)-acrylic acid (3,4′-AAZCPE) was fabricated. The electrochemical study of the modified electrode, as well as its efficiency for the electrocatalytic oxidation of levodopa, is described. The electrode was employed to study the electrocatalytic oxidation of levodopa, using cyclic voltammetry (CV), chronoamperometry (CHA), and square-wave voltammetry (SWV) as diagnostic techniques. It has been found that the oxidation of levodopa at the surface of the modified electrode occurs at a potential of about 370 mV less positive than that of an unmodified carbon paste electrode. The SWV results exhibit a linear dynamic range from 1.0 × 10−7 M to 7.0 × 10−5 M and a detection limit of 3.5 × 10−8 M for levodopa. In addition, this modified electrode was used for the simultaneous determination of levodopa and carbidopa. Finally, the modified electrode was used for the determination of levodopa and carbidopa in some real samples.

Graphical abstract: Synthesis of ZnO nanorods and their application in the construction of a nanostructure-based electrochemical sensor for determination of levodopa in the presence of carbidopa

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Article information


Submitted
19 Jan 2014
Accepted
05 Mar 2014
First published
06 Mar 2014

Analyst, 2014,139, 4356-4364
Article type
Paper
Author version available

Synthesis of ZnO nanorods and their application in the construction of a nanostructure-based electrochemical sensor for determination of levodopa in the presence of carbidopa

E. Molaakbari, A. Mostafavi, H. Beitollahi and R. Alizadeh, Analyst, 2014, 139, 4356
DOI: 10.1039/C4AN00138A

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