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Issue 1, 2014
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Target-induced quenching for highly sensitive detection of nucleic acids based on label-free luminescent supersandwich DNA/silver nanoclusters

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Abstract

Luminescent silver nanoclusters (AgNCs) were anchored by designed oligonucleotides, acting as fluorescent labels. They hybridized with specific nucleic acid targets to form a supersandwich structure resulting in the fluorescence intensity of the DNA/AgNCs decreasing linearly with respect to the concentration of the target DNA.

Graphical abstract: Target-induced quenching for highly sensitive detection of nucleic acids based on label-free luminescent supersandwich DNA/silver nanoclusters

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Supplementary files

Article information


Submitted
08 Sep 2013
Accepted
08 Oct 2013
First published
08 Oct 2013

Analyst, 2014,139, 165-169
Article type
Paper

Target-induced quenching for highly sensitive detection of nucleic acids based on label-free luminescent supersandwich DNA/silver nanoclusters

G. Wang, Y. Zhu, L. Chen, L. Wang and X. Zhang, Analyst, 2014, 139, 165 DOI: 10.1039/C3AN01702H

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