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Issue 29, 2014
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Insulin-based regulation of glucose-functionalized nanoparticle uptake in muscle cells

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Abstract

Effective regulation of nanoparticle (NP) uptake facilitates the NP-based therapeutics and diagnostics. Here, we report the use of insulin and 2-deoxyglucose (2-DG) to modulate the cellular uptake of glucose-functionalized quantum dots (Glc-QDs) in C2C12 muscle cells. The cellular uptake of Glc-QDs can be modulated up to almost two-fold under insulin stimulation while be down-regulated in the presence of 2-DG. These results demonstrate the use of secondary regulators to control the cellular uptake of NPs through membrane protein recognition in a specific and fine-tunable fashion.

Graphical abstract: Insulin-based regulation of glucose-functionalized nanoparticle uptake in muscle cells

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Publication details

The article was received on 16 Apr 2014, accepted on 21 May 2014 and first published on 21 May 2014


Article type: Paper
DOI: 10.1039/C4TB00608A
J. Mater. Chem. B, 2014,2, 4610-4614

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    Insulin-based regulation of glucose-functionalized nanoparticle uptake in muscle cells

    Y. Yeh, S. T. Kim, R. Tang, B. Yan and V. M. Rotello, J. Mater. Chem. B, 2014, 2, 4610
    DOI: 10.1039/C4TB00608A

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