Jump to main content
Jump to site search

Issue 27, 2014
Previous Article Next Article

Merging of covalent cross-linking and biomimetic mineralization into an LBL self-assembly process for the construction of robust organic–inorganic hybrid microcapsules

Author affiliations

Abstract

A mild and efficient method for the construction of robust organic–inorganic hybrid microcapsules was developed by merging of covalent cross-linking and biomimetic mineralization into a layer-by-layer (LBL) self-assembly process. The diatom cell-inspired microcapsule structure had a biocompatible inner organic layer which could create a suitable microenvironment for biologically active substances inside the microcapsules and an inorganic layer which could function as a supporting membrane to maintain the intact morphology of the microcapsules. When in 40% PSS solution, only 5% of the hybrid microcapsules were deformed indicating that the hybrid microcapsule had a higher mechanical stability. The combination of the advantages of both the organic layer and the inorganic layer was applied for the immobilization of catalase (CAT). After being reused 7 times, the CAT in the hybrid microcapsules retained 78% of its initial activity. A buffering effect was created by the capsule wall and the immobilized CAT had a higher pH stability than the free CAT. After storing for 45 days, the CAT in the hybrid microcapsules retained 78% of its initial activity. It is envisaged that the as-prepared hybrid microcapsules can be extended to many applications such as biocatalysis, drug/gene delivery and biosensor fields.

Graphical abstract: Merging of covalent cross-linking and biomimetic mineralization into an LBL self-assembly process for the construction of robust organic–inorganic hybrid microcapsules

Back to tab navigation

Article information


Submitted
13 Feb 2014
Accepted
30 Apr 2014
First published
05 May 2014

J. Mater. Chem. B, 2014,2, 4346-4355
Article type
Paper

Merging of covalent cross-linking and biomimetic mineralization into an LBL self-assembly process for the construction of robust organic–inorganic hybrid microcapsules

C. Tian, C. Zhang, H. Wu, Y. Song, J. Shi, X. Wang, X. Song, C. Yang and Z. Jiang, J. Mater. Chem. B, 2014, 2, 4346
DOI: 10.1039/C4TB00243A

Social activity

Search articles by author

Spotlight

Advertisements