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Issue 1, 2015
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Dual secured nano-melittin for the safe and effective eradication of cancer cells

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Abstract

The clinical application of natural and synthetic amphipathic peptides (e.g., melittin) for cancer therapy is hindered by their notorious side effect, lysing red blood cells. To safely deliver a therapeutic peptide to the tumor tissue and kill cancer cells, we developed an environment-sensitive peptide delivery system, dual secured nano-sting (DSNS), through the combination of a zwitterionic glycol chitosan and disulfide bonds. Melittin loaded DSNS could kill almost 100% of MCF-7, HCT-116, SKOV-3, and NCI/ADR-RES (multidrug resistant) cancer cells at the concentration of 5 μM, while not showing any hemolytic effect.

Graphical abstract: Dual secured nano-melittin for the safe and effective eradication of cancer cells

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Supplementary files

Article information


Submitted
22 Aug 2014
Accepted
28 Oct 2014
First published
28 Oct 2014

J. Mater. Chem. B, 2015,3, 25-29
Article type
Communication
Author version available

Dual secured nano-melittin for the safe and effective eradication of cancer cells

B. Cheng, B. Thapa, R. K. C. and P. Xu, J. Mater. Chem. B, 2015, 3, 25
DOI: 10.1039/C4TB01401D

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