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Issue 47, 2014
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Water-soluble photoluminescent d-mannose and l-alanine functionalized silicon nanocrystals and their application to cancer cell imaging

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Abstract

Herein, we report the straightforward synthesis, photoluminescent properties, and cell imaging studies of D-mannose and L-alanine functionalized silicon nanocrystals (SiNCs). Tailoring nanocrystal surface functionalization is essential to interfacing SiNCs with their environment and rendering them stable – surface modification also offers the opportunity to target specific cell types for imaging. A simple and versatile surface modification procedure was developed to tether biomolecules onto the SiNC surfaces and render them water-soluble. The presented approach is precious metal-catalyst free, straightforward, and provides carbohydrate and amino acid functionalized SiNCs. The functionalized SiNCs have been investigated by fluorescence microscopy and our results indicate that they can be internalized by MCF-7 human breast cancer cells as shown in the cell imaging studies. The obtained SiNCs were characterized using FTIR, XPS, PL, and TEM.

Graphical abstract: Water-soluble photoluminescent d-mannose and l-alanine functionalized silicon nanocrystals and their application to cancer cell imaging

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Supplementary files

Article information


Submitted
15 Jul 2014
Accepted
15 Oct 2014
First published
22 Oct 2014

This article is Open Access

J. Mater. Chem. B, 2014,2, 8427-8433
Article type
Paper
Author version available

Water-soluble photoluminescent D-mannose and L-alanine functionalized silicon nanocrystals and their application to cancer cell imaging

Y. Zhai, M. Dasog, R. B. Snitynsky, T. K. Purkait, M. Aghajamali, A. H. Hahn, C. B. Sturdy, T. L. Lowary and J. G. C. Veinot, J. Mater. Chem. B, 2014, 2, 8427
DOI: 10.1039/C4TB01161A

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