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Issue 35, 2014
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Blood compatible materials: state of the art

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Devices that function in contact with blood are ubiquitous in clinical medicine and biotechnology. These devices include vascular grafts, coronary stents, heart valves, catheters, hemodialysers, heart-lung bypass systems and many others. Blood contact generally leads to thrombosis (among other adverse outcomes), and no material has yet been developed which remains thrombus-free indefinitely and in all situations: extracorporeally, in the venous circulation and in the arterial circulation. In this article knowledge on blood–material interactions and “thromboresistant” materials is reviewed. Current approaches to the development of thromboresistant materials are discussed including surface passivation; incorporation and/or release of anticoagulants, antiplatelet agents and thrombolytic agents; and mimicry of the vascular endothelium.

Graphical abstract: Blood compatible materials: state of the art

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The article was received on 31 May 2014, accepted on 16 Jul 2014 and first published on 17 Jul 2014

Article type: Feature Article
DOI: 10.1039/C4TB00881B
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J. Mater. Chem. B, 2014,2, 5718-5738

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    Blood compatible materials: state of the art

    X. Liu, L. Yuan, D. Li, Z. Tang, Y. Wang, G. Chen, H. Chen and J. L. Brash, J. Mater. Chem. B, 2014, 2, 5718
    DOI: 10.1039/C4TB00881B

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