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Issue 6, 2014
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Polymer-coated spherical mesoporous silica for pH-controlled delivery of insulin

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Abstract

We report a pH-controlled insulin release system to provide an oral administration route. Mesoporous silica was chosen as a drug carrier, and pH-sensitive polymers were coated onto spherical mesocellular foam with pre-adsorbed insulin. We evaluated the insulin release in both acidic and neutral solutions to compare how this system behaves under different pH conditions.

Graphical abstract: Polymer-coated spherical mesoporous silica for pH-controlled delivery of insulin

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Publication details

The article was received on 23 Oct 2013, accepted on 28 Nov 2013 and first published on 02 Dec 2013


Article type: Communication
DOI: 10.1039/C3TB21494J
J. Mater. Chem. B, 2014,2, 616-619

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    Polymer-coated spherical mesoporous silica for pH-controlled delivery of insulin

    S. R. Choi, D. Jang, S. Kim, S. An, J. Lee, E. Oh and J. Kim, J. Mater. Chem. B, 2014, 2, 616
    DOI: 10.1039/C3TB21494J

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