Jump to main content
Jump to site search

Issue 7, 2014
Previous Article Next Article

Development of an efficient transdermal drug delivery system with TAT-conjugated cationic polymeric lipid vesicles

Author affiliations

Abstract

Conventional liposomes (CLs) have been used as a transdermal drug delivery system for enhancing the delivery of hydrophilic drugs into/through the skin. However, their applications have been constrained by their limited penetration ability and poor stability. In this article, a new kind of transactivating transcriptional activator peptide (TAT)-conjugated polymeric lipid vesicles (TPLVs) formed from amphiphilic lysine–linoleic acid modified dextran (LLD) and cholesterol (Chol) has been prepared successfully. The newly developed TPLVs had a bilayer structure similar to CLs. The TPLVs also have smaller particle size, narrower distribution, higher positive charge and much better stability than the CLs; they remained stable in aqueous solutions for up to 60 days without aggregation. The in vitro and in vivo skin permeation studies revealed that TPLVs delivered a higher amount of drug through the skin than CLs, indicating enhanced drug transdermal activities. The synergetic effects of abovementioned features and the cell-penetrating peptide TAT might have contributed to the improved skin penetration ability of the TPLVs. Similar to CLs, TPLVs began to show limited cytotoxicity against human umbilical vein endothelial cells at a concentration of 200 μg mL−1. The in vitro release profiles showed that the TPLVs achieved a sustained release of lidocaine. These results suggest that the TPLVs may be utilized as an efficient carrier to replace CLs for transdermal drug delivery.

Graphical abstract: Development of an efficient transdermal drug delivery system with TAT-conjugated cationic polymeric lipid vesicles

Back to tab navigation

Article information


Submitted
29 Sep 2013
Accepted
22 Nov 2013
First published
29 Nov 2013

J. Mater. Chem. B, 2014,2, 877-884
Article type
Paper

Development of an efficient transdermal drug delivery system with TAT-conjugated cationic polymeric lipid vesicles

S. Wang, D. Zeng, J. Niu, H. Wang, L. Wang, Q. Li, C. Li, H. Song, J. Chang and L. Zhang, J. Mater. Chem. B, 2014, 2, 877 DOI: 10.1039/C3TB21353F

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.


Social activity

Search articles by author

Spotlight

Advertisements