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Issue 8, 2014
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Stepwise DNA condensation by a histone-mimic peptide-coated M12L24 spherical complex

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Abstract

A nanosized M12L24 coordination sphere mimicking a histone-octamer, in size and charge density, was studied as an artificial DNA compaction core. It triggered a stepwise condensation process in a similar manner to that of the natural system. “Beads-on-a-string” and “multistrand aggregation” intermediates were clearly observed by atomic force microscopy (AFM) and dynamic light scattering (DLS) studies during the condensation process.

Graphical abstract: Stepwise DNA condensation by a histone-mimic peptide-coated M12L24 spherical complex

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Supplementary files

Article information


Submitted
03 Mar 2014
Accepted
13 Mar 2014
First published
29 Apr 2014

Chem. Sci., 2014,5, 3257-3260
Article type
Edge Article

Stepwise DNA condensation by a histone-mimic peptide-coated M12L24 spherical complex

T. Kikuchi, S. Sato, D. Fujita and M. Fujita, Chem. Sci., 2014, 5, 3257
DOI: 10.1039/C4SC00656A

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