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Issue 8, 2019
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A modular approach to prepare enantioenriched cyclobutanes: synthesis of (+)-rumphellaone A

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Abstract

A modular synthesis of enantioenriched polyfunctionalized cyclobutanes was developed that features an 8-aminoquinolinamide directed C–H arylation reaction. The C–H arylation products were derivatized through subsequent decarboxylative coupling processes. This synthetic strategy enabled a 9-step enantioselective total synthesis of the antiproliferative meroterpenoid (+)-rumphellaone A.

Graphical abstract: A modular approach to prepare enantioenriched cyclobutanes: synthesis of (+)-rumphellaone A

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Publication details

The article was received on 06 Dec 2018, accepted on 19 Dec 2018 and first published on 19 Dec 2018


Article type: Edge Article
DOI: 10.1039/C8SC05444D
Chem. Sci., 2019,10, 2315-2319
  • Open access: Creative Commons BY-NC license
    All publication charges for this article have been paid for by the Royal Society of Chemistry

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    A modular approach to prepare enantioenriched cyclobutanes: synthesis of (+)-rumphellaone A

    J. C. Beck, C. R. Lacker, L. M. Chapman and S. E. Reisman, Chem. Sci., 2019, 10, 2315
    DOI: 10.1039/C8SC05444D

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