Jordan C. Beck, Caitlin R. Lacker, Lauren M. Chapman and Sarah E. Reisman
Chem. Sci., 2019,10, 2315-2319
DOI:
10.1039/C8SC05444D,
Edge Article
A modular synthesis of enantioenriched polyfunctionalized cyclobutanes was developed that features an 8-aminoquinolinamide directed C–H arylation reaction. The C–H arylation products were derivatized through subsequent decarboxylative coupling processes. This synthetic strategy enabled a 9-step enantioselective total synthesis of the antiproliferative meroterpenoid (+)-rumphellaone A.