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Issue 6, 2014
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Bioorthogonal chemistry in living organisms

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Bioorthogonal chemistry allows for selective and efficient modification of biomolecules in their natural environment. Several strategies have been developed over the past years that employ cellular biosynthetic pathways to incorporate the desired functionalities. These moieties in turn efficiently react with exogenously added complementary reaction partners. This field has now moved forward from a conceptual phase to the application of these methodologies in living systems. In this perspective, we highlight recent and exciting developments pertaining to the use of bioorthogonal chemistry in living organisms.

Graphical abstract: Bioorthogonal chemistry in living organisms

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Article information

04 Oct 2013
23 Dec 2013
First published
02 Jan 2014

Chem. Sci., 2014,5, 2123-2134
Article type

Bioorthogonal chemistry in living organisms

A. Borrmann and J. C. M. van Hest, Chem. Sci., 2014, 5, 2123
DOI: 10.1039/C3SC52768A

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