Issue 14, 2014
From the journal:

RSC Advances

Anticancer activity of 4-aminoquinoline-triazine based molecular hybrids†

Sunny Manohar,a   Antonella Pepe,b   Christian E. Vélez Gerena,c   Beatriz Zayas,c   Sanjay V. Malhotra*b  and  Diwan S. Rawat*a  

* Corresponding authors

a Department of Chemistry, University of Delhi, Delhi-110007, India
E-mail: dsrawat@chemistry.du.ac.in
Fax: +91-11-27667501
Tel: +91-11-27662683

b Laboratory of Synthetic Chemistry, SAIC-Frederick Inc., Frederick National Laboratory for Cancer Research, Frederick, MD 21702, USA
E-mail: malhotrasa@mail.nih.gov
Tel: +1-301-846-5141

c School of Environmental Affairs, Universidad Metropolitana, San Juan, Puerto Rico, USA

Abstract

In this study the potential for anticancer activity of 4-aminoquinoline-triazine based hybrids has been investigated on 60 human cancer cell lines (NCI 60). The representative compounds show activity on a range of cell lines and apoptosis as the mode of growth inhibition.

Graphical abstract: Anticancer activity of 4-aminoquinoline-triazine based molecular hybrids

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Article information

DOI
https://doi.org/10.1039/C3RA45333B
Article type
Paper
Submitted
25 Sep 2013
Accepted
21 Nov 2013
First published
25 Nov 2013

RSC Adv., 2014,4, 7062-7067

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Anticancer activity of 4-aminoquinoline-triazine based molecular hybrids

S. Manohar, A. Pepe, C. E. Vélez Gerena, B. Zayas, S. V. Malhotra and D. S. Rawat, RSC Adv., 2014, 4, 7062 DOI: 10.1039/C3RA45333B

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