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Issue 107, 2014
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Direct C–H amination and C–H chloroamination of 7-deazapurines

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Abstract

Protocols for selective Pd–Cu-catalyzed direct C–H amination or C–H chloroamination of 7-deazapurines with N-chloro-N-alkyl-arylsulfonamides have been developed leading either to 8-(arylsulfonyl)methylamino-7-deazapurines or to 7-chloro-8-(arylsulfonyl)methylamino-7-deazapurines. The scope and limitations of the methods, as well as synthesis of a small series of 6,8,9-tri- and 6,7,8,9-tetrasubstituted 7-deazapurines and deprotection of the sulfonamide are presented.

Graphical abstract: Direct C–H amination and C–H chloroamination of 7-deazapurines

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Supplementary files

Article information


Submitted
25 Oct 2014
Accepted
12 Nov 2014
First published
12 Nov 2014

This article is Open Access

RSC Adv., 2014,4, 62140-62143
Article type
Paper
Author version available

Direct C–H amination and C–H chloroamination of 7-deazapurines

N. Sabat, M. Klečka, L. Slavětínská, B. Klepetářová and M. Hocek, RSC Adv., 2014, 4, 62140
DOI: 10.1039/C4RA13143F

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