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Issue 86, 2014
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The construction of cell-density controlled three-dimensional tissues by coating micrometer-sized collagen fiber matrices on single cell surfaces

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Abstract

Type I collagen fibers were coated onto single cell surfaces by capitalizing on the formation of collagen microfibers at a neutral pH and exploiting cell membrane interactions between collagen fibers and integrin receptors. Collagen fiber coat thicknesses were controllable from 3 to 30 μm. Multi-layered tissues with controllable thicknesses and cell densities were successfully constructed depending on the thickness of micrometer-sized collagen matrices.

Graphical abstract: The construction of cell-density controlled three-dimensional tissues by coating micrometer-sized collagen fiber matrices on single cell surfaces

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Publication details

The article was received on 22 Aug 2014, accepted on 12 Sep 2014 and first published on 15 Sep 2014


Article type: Communication
DOI: 10.1039/C4RA09085C
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RSC Adv., 2014,4, 46141-46144

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    The construction of cell-density controlled three-dimensional tissues by coating micrometer-sized collagen fiber matrices on single cell surfaces

    C. Liu, M. Matsusaki and M. Akashi, RSC Adv., 2014, 4, 46141
    DOI: 10.1039/C4RA09085C

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