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Issue 86, 2014
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Asymmetric transfer hydrogenation of imines in water/methanol co-solvent system and mechanistic investigation by DFT study

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Abstract

Asymmetric transfer hydrogenation of various cyclic imines proceeded efficiently with water/methanol co-solvent media in 20 min with excellent yields and enantioselectivities by employing Rh–TsDPEN catalyst and sodium formate as a hydrogen donor. The role of the co-solvent in enhanced productivity of the reaction was investigated by DFT. The mechanism for ATH of the imines has been discussed on the basis of the DFT study.

Graphical abstract: Asymmetric transfer hydrogenation of imines in water/methanol co-solvent system and mechanistic investigation by DFT study

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The article was received on 01 Aug 2014, accepted on 05 Sep 2014 and first published on 08 Sep 2014


Article type: Communication
DOI: 10.1039/C4RA07964G
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RSC Adv., 2014,4, 46351-46356

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    Asymmetric transfer hydrogenation of imines in water/methanol co-solvent system and mechanistic investigation by DFT study

    V. S. Shende, S. K. Shingote, S. H. Deshpande, N. Kuriakose, K. Vanka and A. A. Kelkar, RSC Adv., 2014, 4, 46351
    DOI: 10.1039/C4RA07964G

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