Issue 99, 2014

45S5 bioactive glass-based scaffolds coated with cellulose nanowhiskers for bone tissue engineering

Abstract

Highly porous 45S5 bioactive glass-based scaffolds prepared by foam replication method were coated with cellulose nanowhiskers by dip coating method. The obtained cellulose nanowhisker-coated scaffolds retained the high porosity and interconnected pore structure. The cellulose coating improved the mechanical properties of the scaffolds and did not hinder their bioactivity in simulated body fluid. In vitro biocompatibility assessment was carried out by qualitative evaluation of the morphology of osteoblast-like cells (MG-63) seeded onto the scaffolds. The cells were shown to attach and spread on both uncoated scaffolds and cellulose nanowhisker-coated scaffolds, thus cellulose nanowhisker coating seems to have no negative influence on the behavior of MG-63 cells. The obtained bioactive and biocompatible composite scaffolds represent promising candidates for bone tissue engineering applications.

Graphical abstract: 45S5 bioactive glass-based scaffolds coated with cellulose nanowhiskers for bone tissue engineering

Article information

Article type
Paper
Submitted
28 Jul 2014
Accepted
10 Oct 2014
First published
10 Oct 2014
This article is Open Access
Creative Commons BY license

RSC Adv., 2014,4, 56156-56164

45S5 bioactive glass-based scaffolds coated with cellulose nanowhiskers for bone tissue engineering

W. Li, N. Garmendia, U. Pérez de Larraya, Y. Ding, R. Detsch, A. Grünewald, J. A. Roether, D. W. Schubert and A. R. Boccaccini, RSC Adv., 2014, 4, 56156 DOI: 10.1039/C4RA07740G

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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