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Issue 59, 2014
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VanadiumV(salen) catalysed synthesis of oxazolidinones from epoxides and isocyanates

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Abstract

The combination of a vanadiumV(salen) complex V+O(salen) EtOSO3 and tetrabutylammonium bromide forms a highly active catalyst system for the reaction between epoxides and isocyanates leading to oxazolidinones. The reaction conditions were optimized and the optimal conditions (80 °C in toluene for 5 hours with 2 mol% of vanadium catalyst and 2 mol% of tetrabutylammonium bromide cocatalyst) applied to eight epoxides and six aromatic isocyanates, giving 18 oxazolidinones with conversions of 34–98% and isolated chemical yields of the major regioisomer of 23–89%.

Graphical abstract: VanadiumV(salen) catalysed synthesis of oxazolidinones from epoxides and isocyanates

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Supplementary files

Article information


Submitted
12 May 2014
Accepted
04 Jul 2014
First published
04 Jul 2014

RSC Adv., 2014,4, 31345-31352
Article type
Paper
Author version available

VanadiumV(salen) catalysed synthesis of oxazolidinones from epoxides and isocyanates

C. Beattie and M. North, RSC Adv., 2014, 4, 31345
DOI: 10.1039/C4RA04427D

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