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Issue 49, 2014
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A turn-on fluorescent probe for imaging lysosomal hydrogen sulfide in living cells

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Abstract

Hydrogen sulfide (H2S) is an endothelial gasotransmitter which has been extensively studied recently in various physiological processes. H2S can induce lysosomal membrane destabilization leading to an autophagic event of precipitation apoptosis coupled with calpain activation, thus ensuring cellular demise. In this study, we developed a lysosome-targetable fluorescent probe for the recognition of H2S with considerable fluorescence enhancement. Through introducing a lysosome-targetable group 4-(2-aminoethyl)-morpholine into the H2S probe N-imide termus of 4-azide-1,8-naphthalimide, the new compound Lyso-AFP can recognize H2S in lysosomes. This probe emerges as a more biocompatible analysis tool with low poison by-product than reported H2S fluorescent probes.

Graphical abstract: A turn-on fluorescent probe for imaging lysosomal hydrogen sulfide in living cells

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Supplementary files

Article information


Submitted
24 Apr 2014
Accepted
30 May 2014
First published
03 Jun 2014

RSC Adv., 2014,4, 25790-25794
Article type
Paper
Author version available

A turn-on fluorescent probe for imaging lysosomal hydrogen sulfide in living cells

Q. Qiao, M. Zhao, H. Lang, D. Mao, J. Cui and Z. Xu, RSC Adv., 2014, 4, 25790
DOI: 10.1039/C4RA03725A

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