Jump to main content
Jump to site search

Issue 23, 2014
Previous Article Next Article

Antibacterial activity of adamantyl substituted cyclohexane diamine derivatives against methicillin resistant Staphylococcus aureus and Mycobacterium tuberculosis

Author affiliations

Abstract

A series of forty two adamantyl based cyclohexane diamine derivatives were synthesized and the antibacterial activities of these compounds were assessed against 29 strains of methicillin resistant Staphylococcus aureus (MRSA) and a virulent strain of Mycobacterium tuberculosis. The compounds showed potent to moderate activity against MRSA while moderate to weak activity against the virulent strain of M. tuberculosis. The compound 8e showed the most potent activity against MRSA having minimum inhibitory concentration (MIC) values in the range of 8–64 μg mL−1 against 26 MRSA strains out of the 29 strains examined. It exhibited improved inhibitory activity compared to oxacillin. Compound 8i with an MIC value of 13.7 μM against M. tuberculosis, was bactericidal with rapid kill kinetics demonstrating a 4 log reduction in viability of M. tuberculosis within 7 days.

Graphical abstract: Antibacterial activity of adamantyl substituted cyclohexane diamine derivatives against methicillin resistant Staphylococcus aureus and Mycobacterium tuberculosis

Back to tab navigation

Supplementary files

Publication details

The article was received on 11 Jan 2014, accepted on 11 Feb 2014 and first published on 18 Feb 2014


Article type: Paper
DOI: 10.1039/C4RA00224E
RSC Adv., 2014,4, 11962-11966

  •   Request permissions

    Antibacterial activity of adamantyl substituted cyclohexane diamine derivatives against methicillin resistant Staphylococcus aureus and Mycobacterium tuberculosis

    Beena, D. Kumar, W. Kumbukgolla, S. Jayaweera, M. Bailey, T. Alling, J. Ollinger, T. Parish and D. S. Rawat, RSC Adv., 2014, 4, 11962
    DOI: 10.1039/C4RA00224E

Search articles by author

Spotlight

Advertisements