Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.


Issue 4, 2014
Previous Article Next Article

Exploring GPTMS reactivity against simple nucleophiles: chemistry beyond hybrid materials fabrication

Author affiliations

Abstract

Hybrid materials with interpenetrating networks of silica and degradable polymers have the potential to outperform current biomaterials as their mechanical properties and degradation rates can be tightly controlled. GPTMS is one of the most widely used precursors for sol–gel hybrid fabrication. It can be used as the silica precursor or as a coupling agent to create hybrids with covalent bonds between the silica and organic components. Understanding its reactivity with nucleophilic groups on organic molecules in aqueous conditions is of key importance to hybrid synthesis. NMR spectrometry assisted by mass spectrometry was successfully used for the investigation of the reaction system of (3-glycidoxypropyl)trimethoxysilane (GPTMS) in the presence of different simple nucleophiles. Inorganic condensation and silica network formation is accelerated in the presence of propylamine; propanoic acid gives nucleophilic attack on the epoxy ring; propanol and propanthiol do not seem to participate in the reaction.

Graphical abstract: Exploring GPTMS reactivity against simple nucleophiles: chemistry beyond hybrid materials fabrication

Back to tab navigation

Supplementary files

Article information


Submitted
29 Aug 2013
Accepted
06 Nov 2013
First published
08 Nov 2013

RSC Adv., 2014,4, 1841-1848
Article type
Paper

Exploring GPTMS reactivity against simple nucleophiles: chemistry beyond hybrid materials fabrication

L. Gabrielli, L. Connell, L. Russo, J. Jiménez-Barbero, F. Nicotra, L. Cipolla and J. R. Jones, RSC Adv., 2014, 4, 1841
DOI: 10.1039/C3RA44748K

Social activity

Search articles by author

Spotlight

Advertisements