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Issue 5, 2014
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Sonogashira coupling in natural product synthesis

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Abstract

This review will focus on selected applications of Sonogashira coupling and subsequent transformations as key steps in the total synthesis of natural products. A brief introduction to the history and development of Sonogashira coupling will be presented. The organization of the synthetic applications is based on the structure of target molecules and the transformations followed by the Sonogashira coupling, which includes (1) preparation of natural products containing conjugated enynes or enediynes; (2) Sonogashira coupling followed by stereoselective reduction and (3) Sonogashira coupling followed by regioselective annulations.

Graphical abstract: Sonogashira coupling in natural product synthesis

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Publication details

The article was received on 30 Dec 2013, accepted on 08 Mar 2014 and first published on 20 Mar 2014


Article type: Review Article
DOI: 10.1039/C3QO00086A
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Org. Chem. Front., 2014,1, 556-566

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    Sonogashira coupling in natural product synthesis

    D. Wang and S. Gao, Org. Chem. Front., 2014, 1, 556
    DOI: 10.1039/C3QO00086A

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