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Issue 6, 2014
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Biocompatible and biodegradable supramolecular assemblies formed with cucurbit[8]uril as a smart platform for reduction-triggered release of doxorubicin

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Abstract

A truly novel strategy for fabricating reducible supramolecular assemblies based on the host–guest interaction between cucurbit[8]uril (CB[8]) and methyl viologen (MV) is reported. The anticancer drug doxorubicin is loaded into the assemblies and a reducing agent Na2S2O4 can be used to successfully trigger release of drugs because of the redox chemistry of MV.

Graphical abstract: Biocompatible and biodegradable supramolecular assemblies formed with cucurbit[8]uril as a smart platform for reduction-triggered release of doxorubicin

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Publication details

The article was received on 02 Nov 2013, accepted on 10 Dec 2013 and first published on 10 Dec 2013


Article type: Communication
DOI: 10.1039/C3PY01538F
Polym. Chem., 2014,5, 1843-1847

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    Biocompatible and biodegradable supramolecular assemblies formed with cucurbit[8]uril as a smart platform for reduction-triggered release of doxorubicin

    J. Zhao, C. Chen, D. Li, X. Liu, H. Wang, Q. Jin and J. Ji, Polym. Chem., 2014, 5, 1843
    DOI: 10.1039/C3PY01538F

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