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Issue 11, 2017
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Virus-like particles composed of sphere-forming polystyrene-block-poly(t-butyl acrylate) (PS-b-PtBA) and control of surface morphology by homopolymer blending

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Abstract

The present report describes the preparation of asymmetric polystyrene-block-poly(t-butyl acrylate) (PS-b-PtBA) particles having virus-like surface structures. Submicron-sized virus-like particles composed of asymmetric polystyrene-block-poly(t-butyl acrylate) (PS-b-PtBA) diblock copolymer particles with a dot pattern on the surface were prepared successfully using a simple solvent evaporation process. Particle surface morphology was controlled by mixing hPS with hPS of varying molecular weights and amounts. These results indicate that the surface morphology of virus-like particles can be controlled using asymmetric diblock copolymers and homopolymers. Deprotection of t-butyl moieties led to the formation of daughter particles with a size in the range of tens of nanometres. This process allows the development of new classes of functional particles useful for immunological diagnosis, drug delivery, and nanoscale-assembled architectures.

Graphical abstract: Virus-like particles composed of sphere-forming polystyrene-block-poly(t-butyl acrylate) (PS-b-PtBA) and control of surface morphology by homopolymer blending

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Article information


Submitted
04 Jan 2017
Accepted
01 Feb 2017
First published
01 Feb 2017

Polym. Chem., 2017,8, 1754-1759
Article type
Paper

Virus-like particles composed of sphere-forming polystyrene-block-poly(t-butyl acrylate) (PS-b-PtBA) and control of surface morphology by homopolymer blending

Y. Hirai, T. Wakiya and H. Yabu, Polym. Chem., 2017, 8, 1754
DOI: 10.1039/C7PY00013H

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