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Issue 10, 2014
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Supramolecular hydrogels assembled from nonionic poly(ethylene glycol)-b-polypeptide diblocks containing OEGylated poly-l-glutamate

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Abstract

A poly(ethylene glycol)-b-poly(γ-(2-methoxyethoxy)esteryl-L-glutamate) (PEG-b-poly-L-EG2Glu) diblock was prepared by the ring-opening polymerization (ROP) of L-EG2Glu N-carboxyanhydride (NCA) using PEG–NH2 as the macroinitiator. When the average degree of polymerization (DP) for poly-L-EG2Glu was below 40, the PEG-b-poly-L-EG2Glu diblock could spontaneously form hydrogels in water. For the different diblocks, a thermally-induced increase in mechanical strength was observed for the PEG-b-poly-L-EG2Glu diblock between 20–45 °C. Transmission electron microscopy (TEM) and atomic force microscopy (AFM) revealed that continuous networks of nanoribbons were formed in these hydrogel samples. Circular dichroism (CD) and Fourier transform infrared spectroscopy (FTIR) characterization suggested that the formation of sufficient β-sheet content accounted for the nanoribbon assemblies and hydrogel networks. The minimal gelation concentration and gel mechanical properties were found to strongly depend on the composition of the PEG-b-poly-L-EG2Glu diblocks.

Graphical abstract: Supramolecular hydrogels assembled from nonionic poly(ethylene glycol)-b-polypeptide diblocks containing OEGylated poly-l-glutamate

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Supplementary files

Article information


Submitted
06 Jan 2014
Accepted
23 Jan 2014
First published
24 Jan 2014

Polym. Chem., 2014,5, 3346-3351
Article type
Paper

Supramolecular hydrogels assembled from nonionic poly(ethylene glycol)-b-polypeptide diblocks containing OEGylated poly-L-glutamate

S. Zhang, W. Fu and Z. Li, Polym. Chem., 2014, 5, 3346
DOI: 10.1039/C4PY00016A

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