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Issue 5, 2014
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Poly[N-(2-hydroxypropyl)methacrylamide] nanogels by RAFT polymerization in inverse emulsion

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Abstract

Inverse emulsion reversible addition-–fragmentation chain transfer (RAFT) polymerization has been used to generate N-(2-hydroxypropyl)methacrylamide (HPMA) based nanoparticles and reduction-sensitive nanogels with diameters of 100–200 nm. Inverse emulsion RAFT homopolymerization of HPMA afforded nanoparticles composed of linear PHPMA macromolecules with relatively narrow molecular weight distributions (Mw/Mn = 1.35–1.55). Copolymerization of HPMA with N,N′-bis(acryloyl)cystamine (BAC) at BAC to chain transfer agent ratios >1.5 resulted in crosslinked nanoparticles that could be isolated and redispersed in water. At smaller BAC to chain transfer agent ratios, non-crosslinked nanoparticles composed of (hyper)branched poly(N-(2-hydroxypropyl)methacrylamide-co-N,N′-bis(acryloyl)cystamine) copolymers were obtained. Addition of protein to the aqueous phase during the inverse emulsion copolymerization of HPMA and BAC allowed preparation of stimuli-responsive, protein-loaded nanogels, which were shown to release their payload under reductive conditions, e.g. upon exposure to tris(2-carboxyethyl)phosphine hydrochloride. These reduction-sensitive nanogels are of interest, e.g. as carriers for the delivery of proteins.

Graphical abstract: Poly[N-(2-hydroxypropyl)methacrylamide] nanogels by RAFT polymerization in inverse emulsion

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Publication details

The article was received on 15 Sep 2013, accepted on 14 Oct 2013 and first published on 14 Oct 2013


Article type: Paper
DOI: 10.1039/C3PY01280H
Polym. Chem., 2014,5, 1711-1719

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    Poly[N-(2-hydroxypropyl)methacrylamide] nanogels by RAFT polymerization in inverse emulsion

    H. Wutzel, F. H. Richter, Y. Li, S. S. Sheiko and H. Klok, Polym. Chem., 2014, 5, 1711
    DOI: 10.1039/C3PY01280H

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