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Issue 4, 2017
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Tracking the formation of supramolecular G-quadruplexes via self-assembly enhanced emission

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Abstract

We report the synthesis and self-assembly of two lipophilic 2′-deoxyguanosine (G) derivatives whose fluorescence intensity is modulated by self-assembly into supramolecular G-quadruplexes (SGQs). Whereas both derivatives self-assemble isostructurally, one shows up to 100% emission enhancement while the other shows an initial enhancement, followed by 10% quenching. Thus, the rotational restrictions resulting from self-assembly are enough to induce significant changes in emission, but it is critical to consider the specific interactions between fluorophores since they will determine the ultimate emission signature. These findings could open the door to the development of luminescent supramolecular sensors and probes.

Graphical abstract: Tracking the formation of supramolecular G-quadruplexes via self-assembly enhanced emission

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Publication details

The article was received on 24 Nov 2016, accepted on 09 Dec 2016 and first published on 13 Dec 2016


Article type: Communication
DOI: 10.1039/C6OB02586B
Citation: Org. Biomol. Chem., 2017,15, 782-786
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    Tracking the formation of supramolecular G-quadruplexes via self-assembly enhanced emission

    D. Silva-Brenes, L. Delgado and J. M. Rivera, Org. Biomol. Chem., 2017, 15, 782
    DOI: 10.1039/C6OB02586B

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