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Issue 44, 2014
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Protein backbone engineering as a strategy to advance foldamers toward the frontier of protein-like tertiary structure

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Abstract

A variety of non-biological structural motifs have been incorporated into the backbone of natural protein sequences. In parallel work, diverse unnatural oligomers of de novo design (termed “foldamers”) have been developed that fold in defined ways. In this Perspective article, we survey foundational studies on protein backbone engineering, with a focus on alterations made in the context of complex tertiary folds. We go on to summarize recent work illustrating the potential promise of these methods to provide a general framework for the construction of foldamer mimics of protein tertiary structures.

Graphical abstract: Protein backbone engineering as a strategy to advance foldamers toward the frontier of protein-like tertiary structure

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Article information


Submitted
18 Aug 2014
Accepted
25 Sep 2014
First published
25 Sep 2014

Org. Biomol. Chem., 2014,12, 8796-8802
Article type
Perspective

Protein backbone engineering as a strategy to advance foldamers toward the frontier of protein-like tertiary structure

Z. E. Reinert and W. S. Horne, Org. Biomol. Chem., 2014, 12, 8796
DOI: 10.1039/C4OB01769B

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