Catalytic asymmetric synthesis of the pentacyclic core of (−)-nakadomarin A via oxazolidine as an iminium cation equivalent
A facile and catalytic asymmetric synthesis of the pentacyclic core of (−)-nakadomarin A, containing all the stereogenic centers of the natural product was achieved. The key intermediate involves the oxazolidine moiety as an iminium cation equivalent. An efficient method for the removal of the N-hydroxyethyl group is also described.
- This article is part of the themed collections: Natural Products in Organic & Biomolecular Chemistry and 2014 Hot Articles in Organic and Biomolecular Chemistry