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Issue 31, 2014
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Fluorous chiral bisoxazolines: application in copper-catalyzed asymmetric α-hydrophosphonylation

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Abstract

A copper-catalyzed asymmetric α-hydrophosphonylation of isatins with a novel fluorous bis(oxazoline) as a ligand is presented. The corresponding chiral α1-oxindole-α-hydroxyphosphonates were obtained in 30–91% yield with enantioselectivities up to 92%. The fluorous ligand can be easily recovered and reused at least 3 times without a significant loss in its activity.

Graphical abstract: Fluorous chiral bisoxazolines: application in copper-catalyzed asymmetric α-hydrophosphonylation

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Article information


Submitted
04 Jun 2014
Accepted
24 Jun 2014
First published
04 Jul 2014

Org. Biomol. Chem., 2014,12, 5843-5846
Article type
Communication

Fluorous chiral bisoxazolines: application in copper-catalyzed asymmetric α-hydrophosphonylation

T. Deng, H. Wang and C. Cai, Org. Biomol. Chem., 2014, 12, 5843
DOI: 10.1039/C4OB01144A

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