Issue 29, 2014

Synthesis and characterization of bisoxazolines- and pybox-copper(ii) complexes and their application in the coupling of α-carbonyls with functionalized amines

Abstract

Binuclear complexes [{(DMOX)CuCl}2(μ-Cl)2] (1), mononuclear complexes [(DMOX)CuBr2] (2) (DMOX = 4,5-dihydro-2-(4,5-dihydro-4,4-dimethyloxazol-2-yl)-4,4-dimethyloxazole) and the pybox Cu(II) complex [(Dm-Pybox)CuBr2] (3) (Dm-Pybox = 2,6-bis[4′,4′-dimethyloxazolin-2′-yl]pyridine) were obtained by reactions of CuX2 (X = Cl, Br) with DMOX and Dm-Pybox ligands, respectively. The molecular structures of 1, 2 and 3 have been determined by single-crystal X-ray diffraction analyses. The complexes 2 and 3 are efficient in catalyzing α-amination of ketones and esters through α-bromo carbonyl intermediate. The procedures are environmentally benign methods using molecular oxygen as an oxidant with water as the only byproduct.

Graphical abstract: Synthesis and characterization of bisoxazolines- and pybox-copper(ii) complexes and their application in the coupling of α-carbonyls with functionalized amines

Supplementary files

Article information

Article type
Paper
Submitted
19 May 2014
Accepted
03 Jun 2014
First published
03 Jun 2014

Org. Biomol. Chem., 2014,12, 5509-5516

Author version available

Synthesis and characterization of bisoxazolines- and pybox-copper(II) complexes and their application in the coupling of α-carbonyls with functionalized amines

W. Jia, D. Li, Y. Dai, H. Zhang, L. Yan, E. Sheng, Y. Wei, X. Mu and K. Huang, Org. Biomol. Chem., 2014, 12, 5509 DOI: 10.1039/C4OB01027B

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