Jump to main content
Jump to site search
PLANNED MAINTENANCE Close the message box

Scheduled maintenance work on Wednesday 22nd May 2019 from 11:00 AM to 1:00 PM (GMT).

During this time our website performance may be temporarily affected. We apologise for any inconvenience this might cause and thank you for your patience.


Issue 38, 2014
Previous Article Next Article

RANEY® cobalt – an underutilised reagent for the selective cleavage of C–X and N–O bonds

Author affiliations

Abstract

RANEY® cobalt, which was first prepared in the 1930s, is known to function effectively as a catalyst for certain chemoselective reductions. However, its utility in chemical synthesis does not seem to have been fully appreciated. This first comprehensive survey of the literature on chemical transformations involving RANEY® cobalt attempts to redress matters by, among other things, highlighting the differences between the performance of this system and its much more well-known but usually less selective congener RANEY® nickel. A reliable method for preparing consistently effective RANEY® cobalt is presented together with a protocol that avoids the need to use it with high pressures of dihydrogen. As such, it is hoped more attention will now be accorded to the title reagent that offers considerable promise as a powerful tool for chemical synthesis, particularly in the assembly of polycyclic frameworks through tandem reductive cyclisation processes.

Graphical abstract: RANEY® cobalt – an underutilised reagent for the selective cleavage of C–X and N–O bonds

Back to tab navigation

Publication details

The article was received on 05 May 2014, accepted on 17 Jun 2014 and first published on 17 Jun 2014


Article type: Review Article
DOI: 10.1039/C4OB00917G
Author version
available:
Download author version (PDF)
Org. Biomol. Chem., 2014,12, 7433-7444

  •   Request permissions

    RANEY® cobalt – an underutilised reagent for the selective cleavage of C–X and N–O bonds

    M. G. Banwell, M. T. Jones, T. A. Reekie, B. D. Schwartz, S. H. Tan and L. V. White, Org. Biomol. Chem., 2014, 12, 7433
    DOI: 10.1039/C4OB00917G

Search articles by author

Spotlight

Advertisements