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Issue 42, 2014
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Triflic acid-promoted cycloisomerization of 2-alkynylphenyl isothiocyanates and isocyanates: a novel synthetic method for a variety of indole derivatives

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Abstract

A new approach towards the synthesis of indole derivatives via triflic acid-promoted cycloisomerization with rearrangement of 2-(alkyn-1-yl)phenyl isothiocyanates and 2-(alkyn-1-yl)phenyl isocyanates has been achieved. By this methodology, structurally diverse types of indole derivatives such as thieno- and furo-indoles, spiro-indolethiones, spiro-oxindoles, and 3-alkylidene-oxindoles were synthesized.

Graphical abstract: Triflic acid-promoted cycloisomerization of 2-alkynylphenyl isothiocyanates and isocyanates: a novel synthetic method for a variety of indole derivatives

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Publication details

The article was received on 22 Apr 2014, accepted on 19 Jun 2014 and first published on 20 Jun 2014


Article type: Paper
DOI: 10.1039/C4OB00825A
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Org. Biomol. Chem., 2014,12, 8398-8407

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    Triflic acid-promoted cycloisomerization of 2-alkynylphenyl isothiocyanates and isocyanates: a novel synthetic method for a variety of indole derivatives

    T. Saito, Y. Sonoki, T. Otani and N. Kutsumura, Org. Biomol. Chem., 2014, 12, 8398
    DOI: 10.1039/C4OB00825A

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