Jump to main content
Jump to site search

Issue 1, 2014
Previous Article Next Article

To be or not to be metal-free: trends and advances in coupling chemistries

Author affiliations

Abstract

Coupling reactions have been part of several extensive studies in order to develop innovative and greener protocols that can generate a wide range of compounds with applications in pharmaceuticals, agrochemicals and biologically active compounds. Metal-free couplings are an important and increasingly trendy field that has attracted a significant deal of interest in recent years, generating a lot of controversy on the issue of whether metal free is really free. Aside from focusing on such a controversial topic itself, this contribution aims to provide a brief introduction on coupling chemistry to point out the transition of this technology from metal-catalyzed to metal-free. This is followed by a range of key selected synthetically useful metal-free processes and a brief commentary on the current debate of whether metal-free reactions are really metal-free and the required experiments for a full understanding of a metal-free coupling process.

Graphical abstract: To be or not to be metal-free: trends and advances in coupling chemistries

Back to tab navigation

Article information


Submitted
30 Aug 2013
Accepted
29 Oct 2013
First published
30 Oct 2013

Org. Biomol. Chem., 2014,12, 10-35
Article type
Review Article

To be or not to be metal-free: trends and advances in coupling chemistries

R. A. D. Arancon, C. Sze Ki Lin, C. Vargas and R. Luque, Org. Biomol. Chem., 2014, 12, 10 DOI: 10.1039/C3OB41768A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.


Social activity

Search articles by author

Spotlight

Advertisements