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Issue 10, 2014
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Point-of-care detection and real-time monitoring of intravenously delivered drugs via tubing with an integrated SERS sensor

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Abstract

We demonstrate an approach for detection, identification, and kinetic monitoring of drugs flowing within tubing, through the use of a plasmonic nanodome array (PNA) surface. The PNA structures are fabricated using a low-cost nanoreplica molding process upon a flexible plastic substrate that is subsequently integrated with a flow cell that connects in series with ordinary intravenous (IV) drug delivery tubing. To investigate the potential clinical applications for point-of-care detection and real-time monitoring, we perform SERS detection of ten pharmaceutical compounds (hydrocodone, levorphanol, morphine, oxycodone, methadone, phenobarbital, dopamine, diltiazem, promethazine, and mitoxantrone). We demonstrate dose-dependent SERS signal magnitude, resulting in detection limits (ng ml−1) well below typical administered dosages (mg ml−1). Further, we show that the detected drugs are not permanently attached to the PNA surface, and thus our approach is capable of performing continuous monitoring of drug delivery as materials flow through IV tubing that is connected in series with the sensor. Finally, we demonstrate the potential co-detection of multiple drugs when they are mixed together, and show excellent reproducibility and stability of SERS measurements for periods extending at least five days. The capabilities reported here demonstrate the potential to use PNA SERS surfaces for enhancing the safety of IV drug delivery.

Graphical abstract: Point-of-care detection and real-time monitoring of intravenously delivered drugs via tubing with an integrated SERS sensor

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Supplementary files

Article information


Submitted
02 Jan 2014
Accepted
21 Mar 2014
First published
26 Mar 2014

Nanoscale, 2014,6, 5162-5171
Article type
Paper
Author version available

Point-of-care detection and real-time monitoring of intravenously delivered drugs via tubing with an integrated SERS sensor

H. Wu and B. T. Cunningham, Nanoscale, 2014, 6, 5162
DOI: 10.1039/C4NR00027G

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