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Issue 5, 2014
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Fungal metabolites with anticancer activity

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Covering: 1964 to 2013

Natural products from bacteria and plants have played a leading role in cancer drug discovery resulting in a large number of clinically useful agents. In contrast, the investigations of fungal metabolites and their derivatives have not led to a clinical cancer drug in spite of significant research efforts revealing a large number of fungi-derived natural products with promising anticancer activity. Many of these natural products have displayed notable in vitro growth-inhibitory properties in human cancer cell lines and select compounds have been demonstrated to provide therapeutic benefits in mouse models of human cancer. Many of these compounds are expected to enter human clinical trials in the near future. The present review discusses the reported sources, structures and biochemical studies aimed at the elucidation of the anticancer potential of these promising fungal metabolites.

Graphical abstract: Fungal metabolites with anticancer activity

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The article was received on 28 Aug 2013 and first published on 20 Mar 2014

Article type: Review Article
DOI: 10.1039/C3NP70078J
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Nat. Prod. Rep., 2014,31, 617-627

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    Fungal metabolites with anticancer activity

    A. Evidente, A. Kornienko, A. Cimmino, A. Andolfi, F. Lefranc, V. Mathieu and R. Kiss, Nat. Prod. Rep., 2014, 31, 617
    DOI: 10.1039/C3NP70078J

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