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Issue 1, 2014
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Industrial natural product chemistry for drug discovery and development

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Abstract

Covering: up to March 2013

In addition to their prominent role in basic biological and chemical research, natural products are a rich source of commercial products for the pharmaceutical and other industries. Industrial natural product chemistry is of fundamental importance for successful product development, as the vast majority (ca. 80%) of commercial drugs derived from natural products require synthetic efforts, either to enable economical access to bulk material, and/or to optimize drug properties through structural modifications. This review aims to illustrate issues on the pathway from lead to product, and how they have been successfully addressed by modern natural product chemistry. It is focused on natural products of current relevance that are, or are intended to be, used as pharmaceuticals.

Graphical abstract: Industrial natural product chemistry for drug discovery and development

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Publication details

The article was received on 01 Jul 2013 and first published on 21 Oct 2013


Article type: Review Article
DOI: 10.1039/C3NP70058E
Nat. Prod. Rep., 2014,31, 35-60

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    Industrial natural product chemistry for drug discovery and development

    A. Bauer and M. Brönstrup, Nat. Prod. Rep., 2014, 31, 35
    DOI: 10.1039/C3NP70058E

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