Issue 10, 2014

Fungal siderophore metabolism with a focus on Aspergillus fumigatus

Abstract

Covering: up to 2014

Siderophores are chelators synthesized by microbes to sequester iron. This article summarizes the knowledge on the fungal siderophore metabolism with a focus on Aspergillus fumigatus. In recent years, A. fumigatus became a role model for fungal biosynthesis, uptake and degradation of siderophores as well as regulation of siderophore-mediated iron handling and the elucidation of siderophore functions. Siderophore functions comprise uptake, intracellular transport and storage of iron. This proved to be crucial not only for adaptation to iron starvation conditions but also for germination, asexual and sexual propagation, antioxidative defense, mutual interaction, microbial competition as well as virulence in plant and animal hosts. Recent studies also indicate the high potential of siderophores and its biosynthetic pathway to improve diagnosis and therapy of fungal infections.

Graphical abstract: Fungal siderophore metabolism with a focus on Aspergillus fumigatus

Article information

Article type
Highlight
Submitted
30 May 2014
First published
20 Aug 2014
This article is Open Access
Creative Commons BY-NC license

Nat. Prod. Rep., 2014,31, 1266-1276

Author version available

Fungal siderophore metabolism with a focus on Aspergillus fumigatus

H. Haas, Nat. Prod. Rep., 2014, 31, 1266 DOI: 10.1039/C4NP00071D

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