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Issue 8, 2014
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Bioactive oligosaccharide natural products

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Abstract

Covering up to December 2013

Oligosaccharide natural products target a wide spectrum of biological processes including disruption of cell wall biosynthesis, interference of bacterial translation, and inhibition of human α-amylase. Correspondingly, oligosaccharides possess the potential for development as treatments of such diverse diseases as bacterial infections and type II diabetes. Despite their potent and selective activities and potential clinical relevance, isolated bioactive secondary metabolic oligosaccharides are less prevalent than other classes of natural products and their biosynthesis has received comparatively less attention. This review highlights the unique modes of action and biosynthesis of four classes of bioactive oligosaccharides: the orthosomycins, moenomycins, saccharomicins, and acarviostatins.

Graphical abstract: Bioactive oligosaccharide natural products

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Article information


Submitted
05 Dec 2013
First published
02 Jun 2014

Nat. Prod. Rep., 2014,31, 1026-1042
Article type
Review Article
Author version available

Bioactive oligosaccharide natural products

E. K. McCranie and B. O. Bachmann, Nat. Prod. Rep., 2014, 31, 1026
DOI: 10.1039/C3NP70128J

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