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Issue 8, 2014
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Recent advances in deep-sea natural products

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Covering: 2009 to 2013.

This review covers the 188 novel marine natural products described since 2008, from deep-water (50–>5000 m) marine fauna including bryozoa, chordata, cnidaria, echinodermata, microorganisms, mollusca and porifera. The structures of the new compounds and details of the source organism, depth of collection and country of origin are presented, along with any relevant biological activities of the metabolites. Where reported, synthetic studies on the deep-sea natural products have also been included. Most strikingly, 75% of the compounds were reported to possess bioactivity, with almost half exhibiting low micromolar cytotoxicity towards a range of human cancer cell lines, along with a significant increase in the number of microbial deep-sea natural products reported.

Graphical abstract: Recent advances in deep-sea natural products

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The article was received on 13 Nov 2013 and first published on 29 May 2014

Article type: Review Article
DOI: 10.1039/C3NP70118B
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Nat. Prod. Rep., 2014,31, 999-1025

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    Recent advances in deep-sea natural products

    D. Skropeta and L. Wei, Nat. Prod. Rep., 2014, 31, 999
    DOI: 10.1039/C3NP70118B

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