Jump to main content
Jump to site search

Issue 3, 2014
Previous Article Next Article

Recent progress with microtubule stabilizers: new compounds, binding modes and cellular activities

Author affiliations

Abstract

Covering: late 2008 to August 2013

Nature has yielded numerous classes of chemically distinct microtubule stabilizers. Several of these, including paclitaxel (Taxol) and docetaxel (Taxotere), are important drugs used in the treatment of cancer. New microtubule stabilizers and novel formulations of these agents continue to provide advances in cancer therapy. In this review we cover recent progress in the chemistry and biology of these diverse microtubule stabilizers focusing on the wide range of organisms that produce these compounds, their mechanisms of inhibiting microtubule-dependent processes, mechanisms of drug resistance, and their interactions with tubulin including their distinct binding sites and modes. A new potential role for microtubule stabilizers in neurodegenerative diseases is reviewed.

Graphical abstract: Recent progress with microtubule stabilizers: new compounds, binding modes and cellular activities

Back to tab navigation

Article information


Submitted
16 Sep 2013
First published
30 Jan 2014

Nat. Prod. Rep., 2014,31, 335-355
Article type
Review Article
Author version available

Recent progress with microtubule stabilizers: new compounds, binding modes and cellular activities

C. C. Rohena and S. L. Mooberry, Nat. Prod. Rep., 2014, 31, 335
DOI: 10.1039/C3NP70092E

Social activity

Search articles by author

Spotlight

Advertisements