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Issue 1, 2014
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The phosphopantetheinyl transferases: catalysis of a post-translational modification crucial for life

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Abstract

Covering: up to 2013

Although holo-acyl carrier protein synthase, AcpS, a phosphopantetheinyl transferase (PPTase), was characterized in the 1960s, it was not until the publication of the landmark paper by Lambalot et al. in 1996 that PPTases garnered wide-spread attention being classified as a distinct enzyme superfamily. In the past two decades an increasing number of papers have been published on PPTases ranging from identification, characterization, structure determination, mutagenesis, inhibition, and engineering in synthetic biology. In this review, we comprehensively discuss all current knowledge on this class of enzymes that post-translationally install a 4′-phosphopantetheine arm on various carrier proteins.

Graphical abstract: The phosphopantetheinyl transferases: catalysis of a post-translational modification crucial for life

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Publication details

The article was received on 11 Jun 2013 and first published on 29 Nov 2013


Article type: Review Article
DOI: 10.1039/C3NP70054B
Nat. Prod. Rep., 2014,31, 61-108

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    The phosphopantetheinyl transferases: catalysis of a post-translational modification crucial for life

    J. Beld, E. C. Sonnenschein, C. R. Vickery, J. P. Noel and M. D. Burkart, Nat. Prod. Rep., 2014, 31, 61
    DOI: 10.1039/C3NP70054B

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