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Issue 6, 2014
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Advances in the chemistry of dendrimers

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Abstract

Dendrimers, which are highly branched, multivalent and monodisperse polymers, have received continuous interest in recent years because of the global demand for new nanomolecules that are useful in advanced technology and medicine. While dendrimers are advantageous for many highly specialised applications, the high polyvalency of higher-generation dendrimers requires, however, well-controlled, target-tailored regioselective chemical engineering. The structural evolution of dendrimers – from simple, monofunctional molecules to the more complex, multifunctional compounds – is inextricably associated with a continuous improvement in traditional synthetic strategies, as well as the development of new synthetic tools. The purpose of this review is to provide insight into currently available synthetic methods that yield dendrimers with various morphologies, placing emphasis on the evaluation of their advantages and limitations. In particular, we will review current efforts that focus on simplifying and optimising the existing methods and the development of new strategies that permit control over the targeted introduction of various functionalities in one or more selected areas of the molecule.

Graphical abstract: Advances in the chemistry of dendrimers

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Supplementary files

Article information


Submitted
09 Oct 2013
Accepted
17 Feb 2014
First published
18 Feb 2014

New J. Chem., 2014,38, 2168-2203
Article type
Perspective

Advances in the chemistry of dendrimers

M. Sowinska and Z. Urbanczyk-Lipkowska, New J. Chem., 2014, 38, 2168
DOI: 10.1039/C3NJ01239E

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