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Issue 10, 2014
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A novel surface-coated nanocarrier for efficient encapsulation and delivery of camptothecin to cells

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Abstract

In the present study, we developed a novel surface-coated nanocarrier (SCN) for efficient and stable encapsulation of a poorly water-soluble anticancer agent, camptothecin (CPT). Using emulsification and freeze-drying processes in the presence of a hydrophilic surfactant, Pluronic F-68 or F-127, CPT–Pluronic complexes with crystalline features were synthesised. Investigation of the in vitro anticancer activities and cellular internalisation of the complexes revealed that the SCN efficiently delivered CPT to cells while maintaining anticancer activity.

Graphical abstract: A novel surface-coated nanocarrier for efficient encapsulation and delivery of camptothecin to cells

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Publication details

The article was received on 21 Apr 2014, accepted on 23 Jul 2014 and first published on 23 Jul 2014


Article type: Concise Article
DOI: 10.1039/C4MD00179F
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Med. Chem. Commun., 2014,5, 1515-1519

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    A novel surface-coated nanocarrier for efficient encapsulation and delivery of camptothecin to cells

    R. Wakabayashi, R. Ishiyama, N. Kamiya and M. Goto, Med. Chem. Commun., 2014, 5, 1515
    DOI: 10.1039/C4MD00179F

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