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Issue 8, 2014
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Design and synthesis of membrane-targeting antibiotics: from peptides- to aminosugar-based antimicrobial cationic amphiphiles

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Abstract

Infections caused by drug resistant and/or slow-growing bacteria are increasingly becoming some of the greatest challenges of health organizations worldwide. The decrease in the efficacy of a large percentage of the current repertoire of clinically used antibiotics against these types of infections emphasizes the need for the development of novel antimicrobial agents that will effectively eradicate a broad spectrum of bacteria regardless of the bacterial cell cycle stage. In this Review, we present recent years' progress in the development of cationic amphiphiles that target the bacterial membrane bilayer as a strategy for the development of antibiotics. Synthesis, antimicrobial activity, membrane selectivity and modes of action aspects are discussed.

Graphical abstract: Design and synthesis of membrane-targeting antibiotics: from peptides- to aminosugar-based antimicrobial cationic amphiphiles

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Publication details

The article was received on 09 Jan 2014, accepted on 24 Feb 2014 and first published on 03 Apr 2014


Article type: Review Article
DOI: 10.1039/C4MD00012A
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Med. Chem. Commun., 2014,5, 1014-1026

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    Design and synthesis of membrane-targeting antibiotics: from peptides- to aminosugar-based antimicrobial cationic amphiphiles

    I. M. Herzog and M. Fridman, Med. Chem. Commun., 2014, 5, 1014
    DOI: 10.1039/C4MD00012A

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