Jump to main content
Jump to site search

Issue 10, 2014
Previous Article Next Article

GPCRserver: an accurate and novel G protein-coupled receptor predictor

Author affiliations

Abstract

G protein coupled receptors (GPCRs), also known as seven-transmembrane domain receptors, pass through the cellular membrane seven times and play diverse biological roles in the cells such as signaling, transporting of molecules and cell–cell communication. In this work, we develop a web server, namely the GPCRserver, which is capable of identifying GPCRs from genomic sequences, and locating their transmembrane regions. The GPCRserver contains three modules: (1) the Trans-GPCR for the transmembrane region prediction by using sequence evolutionary profiles with the assistance of neural network training, (2) the SSEA-GPCR for identifying GPCRs from genomic data by using secondary structure element alignment, and (3) the PPA-GPCR for identifying GPCRs by using profile-to-profile alignment. Our predictor was strictly benchmarked and showed its favorable performance in the real application. The web server and stand-alone programs are publicly available at http://genomics.fzu.edu.cn/GPCR/index.html.

Graphical abstract: GPCRserver: an accurate and novel G protein-coupled receptor predictor

Back to tab navigation

Supplementary files

Article information


Submitted
05 May 2014
Accepted
04 Jul 2014
First published
04 Jul 2014

Mol. BioSyst., 2014,10, 2495-2504
Article type
Method
Author version available

GPCRserver: an accurate and novel G protein-coupled receptor predictor

R. Yan, X. Wang, L. Huang, J. Lin, W. Cai and Z. Zhang, Mol. BioSyst., 2014, 10, 2495 DOI: 10.1039/C4MB00272E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.


Search articles by author

Spotlight

Advertisements