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Issue 12, 2014

Evolutionary game theory: molecules as players

Author affiliations

Abstract

In this and an accompanying paper we review the use of game theoretical concepts in cell biology and molecular biology. This review focuses on the subcellular level by considering viruses, genes, and molecules as players. We discuss in which way catalytic RNA can be treated by game theory. Moreover, genes can compete for success in replication and can have different strategies in interactions with other genetic elements. Also transposable elements, or “jumping genes”, can act as players because they usually bear different traits or strategies. Viruses compete in the case of co-infecting a host cell. Proteins interact in a game theoretical sense when forming heterodimers. Finally, we describe how the Shapley value can be applied to enzymes in metabolic pathways. We show that game theory can be successfully applied to describe and analyse scenarios at the molecular level resulting in counterintuitive conclusions.

Graphical abstract: Evolutionary game theory: molecules as players

Article information


Submitted
20 Dec 2013
Accepted
07 Aug 2014
First published
07 Aug 2014

This article is Open Access

Mol. BioSyst., 2014,10, 3066-3074
Article type
Review Article
Author version available

Evolutionary game theory: molecules as players

K. Bohl, S. Hummert, S. Werner, D. Basanta, A. Deutsch, S. Schuster, G. Theißen and A. Schroeter, Mol. BioSyst., 2014, 10, 3066 DOI: 10.1039/C3MB70601J

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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