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Issue 1, 2014
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Iodotyrosine deiodinase: a unique flavoprotein present in organisms of diverse phyla

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Abstract

Iodide is required for thyroid hormone synthesis in mammals and other vertebrates. The role of both iodide and iodinated tyrosine derivatives is currently unknown in lower organisms, yet the presence of a key enzyme in iodide conservation, iodotyrosine deiodinase (IYD), is suggested by genomic data from a wide range of multicellular organisms as well as some bacteria. A representative set of these genes has now been expressed, and the resulting enzymes all catalyze reductive deiodination of diiodotyrosine with kcat/Km values within a single order of magnitude. This implies a physiological presence of iodotyrosines (or related halotyrosines) and a physiological role for their turnover. At least for Metazoa, IYD should provide a new marker for tracing the evolutionary development of iodinated amino acids as regulatory signals through the tree of life.

Graphical abstract: Iodotyrosine deiodinase: a unique flavoprotein present in organisms of diverse phyla

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Publication details

The article was received on 11 Sep 2013, accepted on 17 Oct 2013 and first published on 17 Oct 2013


Article type: Paper
DOI: 10.1039/C3MB70398C
Mol. BioSyst., 2014,10, 86-92
  • Open access: Creative Commons BY-NC license
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    Iodotyrosine deiodinase: a unique flavoprotein present in organisms of diverse phyla

    A. Phatarphekar, J. M. Buss and S. E. Rokita, Mol. BioSyst., 2014, 10, 86
    DOI: 10.1039/C3MB70398C

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