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Issue 14, 2014
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Magnetic sensing technology for molecular analyses

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Abstract

Magnetic biosensors, based on nanomaterials and miniature electronics, have emerged as a powerful diagnostic platform. Benefiting from the inherently negligible magnetic background of biological objects, magnetic detection is highly selective even in complex biological media. The sensing thus requires minimal sample purification and yet achieves a high signal-to-background contrast. Moreover, magnetic sensors are also well-suited for miniaturization to match the size of biological targets, which enables sensitive detection of rare cells and small amounts of molecular markers. We herein summarize recent advances in magnetic sensing technologies, with an emphasis on clinical applications in point-of-care settings. Key components of sensors, including magnetic nanomaterials, labeling strategies and magnetometry, are reviewed.

Graphical abstract: Magnetic sensing technology for molecular analyses

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Article information


Submitted
12 Mar 2014
Accepted
12 May 2014
First published
02 Jun 2014

Lab Chip, 2014,14, 2385-2397
Article type
Critical Review

Magnetic sensing technology for molecular analyses

D. Issadore, Y. I. Park, H. Shao, C. Min, K. Lee, M. Liong, R. Weissleder and H. Lee, Lab Chip, 2014, 14, 2385
DOI: 10.1039/C4LC00314D

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